SML1162
5-Fluoro-1-propargyl-uracil
≥98% (HPLC)
Synonym(s):
1-Propargyl-5-fluorouracil, 5-Fluoro-1-(2-propyn-1-yl)-2,4(1H,3H)-pyrimidinedione
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About This Item
Empirical Formula (Hill Notation):
C7H5FN2O2
CAS Number:
Molecular Weight:
168.13
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 1 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
O=C1C(F)=CN(CC#C)C(N1)=O
InChI
1S/C7H5FN2O2/c1-2-3-10-4-5(8)6(11)9-7(10)12/h1,4H,3H2,(H,9,11,12)
InChI key
GMCOGJQJFDQZCP-UHFFFAOYSA-N
Biochem/physiol Actions
5-Fluoro-1-propargyl-uracil is a biologically inert precursor, a prodrug that can be bioorthogonally activated to 5-fluorouracil iside a tumor that has a previously implanted palladium catalyst. Preliminary tests with pancreatic and colorectal cancer cells resulted in the death of than 80% of the malignant cells.
5-Fluoro-1-propargyl-uracil is a biologically inert precursor, a prodrug that can be bioorthogonally activated to 5-fluorouracil.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1162-25MG | 04061833025901 |
| SML1162-5MG | 04061833025918 |