SML1169
Pitstop 2
≥98% (HPLC), powder, clathrin-mediated endocytosis inhibitor
Synonym(s):
N-[5-[(4-Bromophenyl)methylene]-4,5-dihydro-4-oxo-2-thiazolyl]-1-naphthalenesulfonamide, Pitstop-2
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About This Item
Empirical Formula (Hill Notation):
C20H13BrN2O3S2
CAS Number:
Molecular Weight:
473.36
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
Pitstop 2, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Application
Pitstop 2 has been used as an inhibitor of clathrin-mediated endocytosis.
Biochem/physiol Actions
Pitstop 2 also has an ability to breakdown the nuclear pore complex (NPC) permeability barrier and decrease importin β binding along with alteration of the NPC ultrastructure. Pitstop 2 is also involved in the inhibition of platelet activation, platelet aggregation and secretion.
Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis.
Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis that acts via blocking ligand access to the clathrin terminal domain. Pitstop 2 selectively inhibits clathrin-mediated HIV entry and stalls clathrin-coated pit (CCP) dynamics.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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Clathrin-mediated integrin ?IIb?3 trafficking controls platelet spreading
Gao W, et al.
Platelets, 1-12 (2017)
Leucine-rich repeat-containing G protein?coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein
Zhang N, et al,
The Journal of Biological Chemistry, 292(40), 16527-16538 (2017)
Clathrin inhibitor Pitstop-2 disrupts the nuclear pore complex permeability barrier
Liashkovich I, et al.
Scientific Reports, 5, 9994-9994 (2015)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML1169-5MG | 04061833225356 |
| SML1169-25MG | 04061833225349 |