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Merck
CN

SML1173

Lubiprostone

≥98% (HPLC)

Synonym(s):

(11a,15R)-11,15-Epoxy-16,16-difluoro-15-hydroxy-9-oxo-prostan-1-oic acid, Ru 0211, Spi 0211

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About This Item

Empirical Formula (Hill Notation):
C20H32F2O5
CAS Number:
136790-76-6
Molecular Weight:
390.46
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

FC(F)([C@@]1(O[C@H]2[C@@H]([C@@H](C(=O)C2)CCCCCCC(=O)O)CC1)O)CCCC

InChI

1S/C20H32F2O5/c1-2-3-11-19(21,22)20(26)12-10-15-14(16(23)13-17(15)27-20)8-6-4-5-7-9-18(24)25/h14-15,17,26H,2-13H2,1H3,(H,24,25)/t14-,15+,17+,20+/m0/s1

InChI key

WGFOBBZOWHGYQH-DKYLXPRQSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Lubiprostone helps to enhance intestinal permeability in humans. Hence it may inhibit leaky gut syndrome.
Lubiprostone is a bicyclic fatty acid that activates ClC-2 and CFTR chloride channels.
Lubiprostone is a bicyclic fatty acid that activates ClC-2 and CFTR chloride channels. Some reports suggest that lubiprostone opens CFTR or both CFTR and ClC-2 through interactions with the prostaglandin receptor EP4. Lubiprostone is used clinically to treat idiopathic chronic constipation and irritible bowel syndrome.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000144644
0000120361
0000120360
0000118631

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Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteers
Kato T, et al.
Testing, 12(4), e0175626-e0175626 (2017)

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