SML1180
WWL229
≥98% (HPLC)
Synonym(s):
2-(3-Methoxypropyl)-1-piperidinecarboxylic acid 4-nitrophenyl ester, 4-Nitrophenyl 2-(3-methoxypropyl)piperidine-1-carboxylate
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About This Item
Empirical Formula (Hill Notation):
C16H22N2O5
CAS Number:
Molecular Weight:
322.36
UNSPSC Code:
12161501
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
oil
Quality Segment
assay
≥98% (HPLC)
form
oil
color
colorless to light yellow
storage temp.
2-8°C
SMILES string
O=C(OC1=CC=C([N+]([O-])=O)C=C1)N2C(CCCOC)CCCC2
InChI
1S/C16H22N2O5/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21/h7-10,13H,2-6,11-12H2,1H3
InChI key
XVBRVSAGMWRVCK-UHFFFAOYSA-N
Biochem/physiol Actions
WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC50 of 10 μM, but not Ces1f, ABHD6 or other tested serine hydrolases. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids that can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes.
WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3).
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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