SML1192
SB290157 trifluoroacetate salt
≥97% (HPLC)
Synonym(s):
N2-[2-(2,2-Diphenylethoxy)acetyl]-L-arginine trifluoroacetate salt, SB 290157 trifluoroacetate salt
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About This Item
Empirical Formula (Hill Notation):
C22H28N4O4 · CF3CO2H
CAS Number:
Molecular Weight:
526.51
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥97% (HPLC)
form
powder
optical activity
[α]/D +1.5 to +5°, c = 1.0 in DMSO
storage condition
desiccated
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
SMILES string
NC(NCCC[C@@H](C(O)=O)NC(COCC(C1=CC=CC=C1)C2=CC=CC=C2)=O)=N.FC(F)(C(O)=O)F
InChI
1S/C22H28N4O4.C2HF3O2/c23-22(24)25-13-7-12-19(21(28)29)26-20(27)15-30-14-18(16-8-3-1-4-9-16)17-10-5-2-6-11-17;3-2(4,5)1(6)7/h1-6,8-11,18-19H,7,12-15H2,(H,26,27)(H,28,29)(H4,23,24,25);(H,6,7)/t19-;/m0./s1
InChI key
ZJRMPPVJAQWGEG-FYZYNONXSA-N
Biochem/physiol Actions
SB290157 is a selective antagonist of complement anaphylatoxin C3a receptor, a 74 amino acid proinflammatory peptide that is a potent chemotaxin for eosinophils, macrophages and mast cells, and has recently been found to be involved in nonimmunological roles in osteoblast differentiation, angiogenesis, and lipid metabolism. SB290157 is selective for C3aR over C5aR or other chemotactic GPCRs with an IC50 of 200 nM. It effectively blocks C3aR in humans, rat, guinea pig, and mouse.SB290157 was found to inhibit diet-induced obesity, metabolic dysfunction, and adipocyte signaling, in addition to inhibiting macrophage signaling.
SB290157 is a selective antagonist of complement anaphylatoxin C3a receptor.
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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