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SML1213

A66

≥98% (HPLC)

Synonym(s):

(2S)-N1-[2-(1,1-Dimethylethyl)-4′-methyl[4,5′-bithiazol]-2′-yl]-1,2-pyrrolidinedicarboxamide

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About This Item

Empirical Formula (Hill Notation):
C17H23N5O2S2
CAS Number:
1166227-08-2
Molecular Weight:
393.53
NACRES:
NA.77
PubChem Substance ID:
329825723
UNSPSC Code:
12352200
MDL number:
MFCD22378485
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(N1[C@H](C(N)=O)CCC1)NC2=NC(C)=C(C3=CSC(C(C)(C)C)=N3)S2

InChI

1S/C17H23N5O2S2/c1-9-12(10-8-25-14(20-10)17(2,3)4)26-15(19-9)21-16(24)22-7-5-6-11(22)13(18)23/h8,11H,5-7H2,1-4H3,(H2,18,23)(H,19,21,24)/t11-/m0/s1

InChI key

HBPXWEPKNBHKAX-NSHDSACASA-N

Biochem/physiol Actions

A66 is a potent and highly selective inhibitor of the phosphoinositide 3-kinase (PI3K) catalytic subunit p110α with an IC50 of 32 nM and >100 fold selectivity for p110α over other class-I PI3K isoforms.
A66 is a potent and highly selective inhibitor of the phosphoinositide 3-kinase (PI3K) catalytic subunit p110α.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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