Key Documents

View All Documentation

SML1221

Dutasteride

Name: Dutasteride
Brand: SIGMA

≥98% (HPLC), 5α-reductase isoenzymes types 1 and 2 inhibitor, powder

Synonym(s):

17β-N-[2,5-Bis(trifluoromethyl)phenyl]carbamoyl-4-aza-5α-androst-1-en-3-one, (5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₇H₃₀F₆N₂O₂

CAS Number:

164656-23-9

Molecular Weight:

528.53

UNSPSC Code:

51111800

PubChem Substance ID:

329825728

NACRES:

NA.77

MDL number:

MFCD00937869

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Product Name

Dutasteride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +18 to +24°, c = 1 in chloroform-d

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C1C=C[C@@]2(C)[C@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4C(NC5=CC(C(F)(F)F)=CC=C5C(F)(F)F)=O)([H])N1

InChI

1S/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17-,19+,21+,24-,25+/m0/s1

InChI key

JWJOTENAMICLJG-QWBYCMEYSA-N

Gene Information

human ... SRD5A1(6715), SRD5A2(6716), SRD5A3(79644)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

Dutasteride is a potent dual inhibitor of 5α-reductase isoenzymes types 1 and 2 (IC₅₀ = 6 nM 5-AR1; 7 nM 5-AR2). Dutasteride blocks testosterone conversion to dihydrotesterone, and is used clinically for treating benign prostatic hyperplasia (BPH).

pictograms

GHS08

signalword

Danger

hcodes

H351,H360FD

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000527569

0000452844

0000416517

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Histologic evaluation of human benign prostatic hyperplasia treated by dutasteride: a study by xenograft model with improved severe combined immunodeficient mice.

Akira Tsujimura et al.

Urology, 85(1), 274-274 (2014-12-03)

To evaluate histologic change in human prostate samples treated with dutasteride and to elucidate direct effects of dutasteride on human prostate tissue, the present study was conducted by using a xenograft model with improved severe combined immunodeficient (super-SCID) mice, although

5α-Reductase Inhibition Coupled with Short Off Cycles Increases Survival in the LNCaP Xenograft Prostate Tumor Model on Intermittent Androgen Deprivation Therapy.

Pascal, L.E., et al.

The Journal of Urology, Oct 31 (2014)

Effects of dihydrotestosterone on osteoblast activity in curdlan-administered SKG mice and osteoprogenitor cells in patients with ankylosing spondylitis.

Sungsin Jo et al.

Arthritis research & therapy, 22(1), 121-121 (2020-05-26)

Ankylosing spondylitis (AS) is characteristically male-predominant, and progressive spinal ankylosis affects male patients more severely; however, the hormonal effects in males with AS are poorly understood. In the present study, the regulatory effects of dutasteride, a 5-α reductase inhibitor that

Dutasteride for the treatment of benign prostatic hyperplasia.

Christopher Wu et al.

Expert opinion on pharmacotherapy, 14(10), 1399-1408 (2013-06-12)

Benign prostatic hyperplasia (BPH) is an age-related phenomenon associated with prostatic enlargement and bladder outlet obstruction that can cause significant lower urinary tract symptoms that greatly affect quality of life. Dutasteride is a selective inhibitor of type 1 and type

Global Trade Item Number

SKU	GTIN
SML1221-10MG	04061832868479
SML1221-50MG	04061837107689

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service