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Merck
CN

SML1223

XBD173

≥98% (HPLC), TSPO ligand, powder

Synonym(s):

AC-5216, Emapunil, N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide, NVP-XBD173

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About This Item

Empirical Formula (Hill Notation):
C23H23N5O2
CAS Number:
226954-04-7
Molecular Weight:
401.46
UNSPSC Code:
12352200
PubChem Substance ID:
329825729
NACRES:
NA.77
MDL number:
MFCD07772312

Key Documents

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Product Name

XBD173, ≥98% (HPLC)

SMILES string

CN(C1=CN=C(C2=CC=CC=C2)N=C1N3CC(N(CC)CC4=CC=CC=C4)=O)C3=O

InChI key

NBMBIEOUVBHEBM-UHFFFAOYSA-N

InChI

1S/C23H23N5O2/c1-3-27(15-17-10-6-4-7-11-17)20(29)16-28-22-19(26(2)23(28)30)14-24-21(25-22)18-12-8-5-9-13-18/h4-14H,3,15-16H2,1-2H3

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

XBD173 (emapunil, AC-5216) is a potent and selective translocator protein 18 kDa (TSPO) ligand with a Ki value of 0.297 nM. XBD173 acts at the TSPO translocator protein, formerly called the peripheral benzodiazepine receptor, which is involved in production of neuroactive steroids such as allopregnanolone in the brain. TSPO carries cholesterol from the outer to the inner mitochondrial membrane, which is the rate-limiting step of steroidogenesis. XBD173 enhances GABA-mediated neurotransmission via induction of neurosteroidogenesis and exhibits anti-anxiety and antidepressant-like effects.
XBD173 is a potent and selective translocator protein.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000466005
0000466005
0000463368
0000463368
0000191291

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