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Merck
CN

SML1224

Torin2

≥98% (HPLC), mTOR inhibitor, powder

Synonym(s):

9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one

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About This Item

Empirical Formula (Hill Notation):
C24H15F3N4O
CAS Number:
1223001-51-1
Molecular Weight:
432.40
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

Torin2, ≥98% (HPLC)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cc(ccc1)[n]2c3c4c(ncc3cc[c]2=O)ccc(c4)c5cnc(cc5)N

InChI

1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)

InChI key

GUXXEUUYCAYESJ-UHFFFAOYSA-N

Related Categories

Application

Torin2 has been used:
  • to examine its effect on LC3B-II levels in BORCS5- KO cells
  • to determine its potent activity (IC50 less than 1 μM) against A2780-cis ovarian cancer cells
  • in western blot analysis

Biochem/physiol Actions

Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor.
Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor. Torin2 has an IC50 of 0.25 nM and 800-fold greater selectivity for mTOR than PI3K.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000053041
0000053041
0000202689
0000200976
0000200976

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AMPK promotes induction of a tumor suppressor FLCN through activation of TFEB independently of mTOR
Collodet C, et al.
bioRxiv, 499921-499921 (2018)
Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells
Sima N, et al.
Translational Oncology, 11(4), 1053-1064 (2018)
BORC coordinates encounter and fusion of lysosomes with autophagosomes
Jia R, et al.
Autophagy, 13(10), 1648-1663 (2017)
Dan Song et al.
Journal of agricultural and food chemistry, 67(28), 7977-7985 (2019-04-02)
2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), one of the most abundant heterocyclic aromatic amines (HAAs) found in the human diet, is primarily produced during high-temperature meat or fish cooking. While MeIQx has been investigated as a potential carcinogen, the cytotoxicity and related molecular mechanisms
Dan Song et al.
Environmental toxicology, 37(7), 1551-1562 (2022-03-04)
The aim of this study was to assess the protective effect and potential mechanism of melatonin against bisphenol A (BPA)-induced apoptosis and oxidative damage in FLK-BLV cells. The results showed that BPA reduced cell viability in a dose- and time-dependent
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