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SML1224

Torin2

Name: Torin2
Brand: SIGMA

≥98% (HPLC), mTOR inhibitor, powder

Synonym(s):

9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₁₅F₃N₄O

CAS Number:

1223001-51-1

Molecular Weight:

432.40

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

Torin2, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cc(ccc1)[n]2c3c4c(ncc3cc[c]2=O)ccc(c4)c5cnc(cc5)N

InChI

1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)

InChI key

GUXXEUUYCAYESJ-UHFFFAOYSA-N

Description

Application

Torin2 has been used:

to examine its effect on LC3B-II levels in BORCS5- KO cells
to determine its potent activity (IC₅₀ less than 1 μM) against A2780-cis ovarian cancer cells
in western blot analysis

Biochem/physiol Actions

Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor.

Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor. Torin2 has an IC₅₀ of 0.25 nM and 800-fold greater selectivity for mTOR than PI3K.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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