SML1234
HAMNO
≥98% (HPLC)
Synonym(s):
(1Z)-1-[(2-Hydroxyanilino)methylidene]naphthalen-2-one, 1-[[(2-Hydroxyphenyl)imino]methyl]-2-naphthalenol, CID 6335338, MLS000737724, NS C111847, NSC111847
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About This Item
Empirical Formula (Hill Notation):
C17H13NO2
CAS Number:
Molecular Weight:
263.29
UNSPSC Code:
12352200
NACRES:
NA.77
InChI key
NADCEWZYITXLKJ-KAMYIIQDSA-N
SMILES string
N(c3c(cccc3)O)\C=C1\c2c(cccc2)C=CC\1=O
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. HAMNO binds the N-terminal domain of RPA70 and inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR. HAMNO enhances DNA replication stress in cancer cells and slow tumor growth in vivo.
HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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