SML1234
HAMNO
≥98% (HPLC)
别名:
(1Z)-1-[(2-Hydroxyanilino)methylidene]naphthalen-2-one, 1-[[(2-Hydroxyphenyl)imino]methyl]-2-naphthalenol, CID 6335338, MLS000737724, NS C111847, NSC111847
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
N(c3c(cccc3)O)\C=C1\c2c(cccc2)C=CC\1=O
InChI key
NADCEWZYITXLKJ-KAMYIIQDSA-N
Biochem/physiol Actions
HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. HAMNO binds the N-terminal domain of RPA70 and inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR. HAMNO enhances DNA replication stress in cancer cells and slow tumor growth in vivo.
HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable