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Merck
CN

SML1252

Treosulfan

≥98% (HPLC), Alkylating agent, powder

Synonym(s):

(2S,3S)-Butanetetraol 1,4-dimesylate, (2S,3S)-Threitol 1,4-bismethanesulfonate, L-Threitol 1,4-bis(methanesulfonate), NSC 39069, Threosulphan, Treosulphan

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About This Item

Empirical Formula (Hill Notation):
C6H14O8S2
CAS Number:
299-75-2
Molecular Weight:
278.30
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

Treosulfan, ≥98% (HPLC)

SMILES string

[S](=O)(=O)(OCC(O)C(O)CO[S](=O)(=O)C)C

InChI

1S/C6H14O8S2/c1-15(9,10)13-3-5(7)6(8)4-14-16(2,11)12/h5-8H,3-4H2,1-2H3

InChI key

YCPOZVAOBBQLRI-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -4.9 to -5.9°, c = 1 in acetone

color

white to beige

solubility

H2O: 5 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Treosulfan is bifunctional alkylating agent.
Alkylating agent, anti-neoplastic agent
Treosulfan is a biofunctional alkylating agent.
Treosulfan/l-threitol-1,4-bis-methanesulfonate; dihydroxybusulfan; NSC 39069. It is a prodrug of a bifunctional alkylating cytotoxic agent. Treosulfan can be activated non-enzymatically to two active epoxides. It is used to treat ovarian cancer.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 1A - Muta. 1B - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000514314
0000514314
0000278139
0000278139
0000192682

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Pre-formulation investigations for establishing a protocol for treosulfan handling and activation
El-Serafi I, et al.
Pharmaceutical Development and Technology, 1-27 (2018)
Treosulfan and fludarabine: a new toxicity-reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation
Casper J, et al.
Blood, 103(2), 725-731 (2004)

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