SML1253
CASIN
≥98% (HPLC), Cdc42 GTPase inhibitor, powder
Synonym(s):
2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol, Cdc42 Activity-Specific Inhibitor
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C20H22N2O
CAS Number:
Molecular Weight:
306.40
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
CASIN, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
, white to very dark brown
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
OCCNC1CCCC2=C1NC3=C2C=C(C4=CC=CC=C4)C=C3
InChI
1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3,5-6,9-10,13,19,21-23H,4,7-8,11-12H2
InChI key
RXIUMAOXORBRCY-UHFFFAOYSA-N
Application
CASIN has been used as a cell division control protein 42 homolog (Cdc42) inhibitor:
- to study its effects on the stimulation of extracellular vesicles (EVs) in intestinal epithelial cells
- to study its effects on mice jejunum
- to study its effects on microbial adhesion-triggered endocytosis (MATE) vesicle morphology in segmented filamentous bacteria (SFB)-colonized mice
Biochem/physiol Actions
CASIN is an inhibitor of Cdc42 GTPase, a small GTPase of the Rho-subfamily that plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking. CASIN generated a rejuvenated phenotype of Hematopoietic stem cells (HSCs), reversing the aging-related and polarity phenotype of aged HSCs to that of young HSCs in vivo..
CASIN is an inhibitor of Cdc42 GTPase.
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.