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SML1271

TWS119

≥98% (HPLC)

Synonym(s):

3-[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy]phenol

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About This Item

Empirical Formula (Hill Notation):
C18H14N4O2
CAS Number:
601514-19-6
Molecular Weight:
318.33
NACRES:
NA.77
PubChem Substance ID:
329825758
UNSPSC Code:
12352200
MDL number:
MFCD09037535
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1

InChI

1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)

InChI key

VPVLEBIVXZSOMQ-UHFFFAOYSA-N

Application

TWS119 has been used as glycogen synthase kinase-3β (GSK-3β) GSK3β inhibitor.

Biochem/physiol Actions

TWS119 favors the γδT cells survival and proliferation by activating the mammalian target of rapamycin (mTOR) pathway. It also promotes the expression of T-cell factor 1 (TCF1) and modulates cytokine production.
TWS119 is a potent Glycogen synthase kinase-3β (GSK-3β) inhibitor that can induce neurogenesis in embryonic stem cells (ESCs).
TWS119 is a potent Glycogen synthase kinase-3β (GSK-3β) inhibitor.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number

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