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Merck
CN

SML1295

RBC8

≥98% (HPLC)

Synonym(s):

6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-pyrano[2,3-c]pyrazole-5-carbonitrile

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About This Item

Empirical Formula (Hill Notation):
C25H20N4O3
CAS Number:
361185-42-4
Molecular Weight:
424.45
NACRES:
NA.77
PubChem Substance ID:
329825769
UNSPSC Code:
12352200
MDL number:
MFCD03341241

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InChI

1S/C25H20N4O3/c1-30-17-9-10-20(31-2)18(12-17)21-19(13-26)24(27)32-25-22(21)23(28-29-25)16-8-7-14-5-3-4-6-15(14)11-16/h3-12,21H,27H2,1-2H3,(H,28,29)

SMILES string

NC1=C(C#N)C(C2=C(OC)C=CC(OC)=C2)C(C(C3=CC=C(C=CC=C4)C4=C3)=NN5)=C5O1

InChI key

CLMQBVUFKIKYLU-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

RBC8 is a selective inhibitor of the Ras-like GTPases RalA and RalB, downstream mediators of Ras signalling, without direct inihibition of Ras or RhoA activity. RBC8 binds to a site on the GDP-bound form of Ral, its inactive state, inhibiting the binding of Ral to its effectors, such as Ral-binding protein 1 (RALBP1; also known as RLIP760, which are involved in proliferation, survival, and metastasis of several human cancers. RBC8 inhibited growth in human luung cancer cell lines with IC50 values of 2.0 μM in H2122 cells and 1.3 μM in H358 cells, and also inihbited tumor xenograft growth..
RBC8 is a selective inhibitor of the Ras-like GTPases RalA and RalB.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000138436
0000032254
0000018261
045M4724V

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