SML1296
6-Thio-2′-Deoxyguanosine
≥97% (HPLC)
Synonym(s):
2′-Ddeoxy-6-thio-guanosine, 2′-Deoxy-6-thioguanosine, 2′-Deoxythioguanosine, 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercaptopurine, 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine-6(1H)-thione (7CI,8CI), 6-Thio-dG, NSC 71261
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Quality Segment
assay
≥97% (HPLC)
form
powder
color
white to brown
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
S=C1C2=C(N([C@H]3C[C@H](O)[C@@H](CO)O3)C=N2)N=C(N)N1
InChI
1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5-,6-/m1/s1
InChI key
SCVJRXQHFJXZFZ-HSUXUTPPSA-N
Application
6-Thio-2′-Deoxyguanosine has been used in secreted luciferase enzyme activity in tonsillar cancer cells.
Biochem/physiol Actions
6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres.
6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres. 6-Thio-2′-deoxyguanosine induces telomere dysfunction and rapid cell death in cancer cells, while spearing telomerase-negative cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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