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Merck
CN

SML1297

SB269652

≥98% (HPLC)

Synonym(s):

N-[trans-4-[2-(7-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-1H-indole-2-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C27H30N4O
CAS Number:
215802-15-6
Molecular Weight:
426.55
UNSPSC Code:
12352200
NACRES:
NA.77

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Product Name

SB269652, ≥98% (HPLC)

SMILES string

[nH]1c2c(cc1C(=O)N[C@@H]3CC[C@H](CC3)CCN4CCc5c(cc(cc5)C#N)C4)cccc2

InChI

1S/C27H30N4O/c28-17-20-5-8-21-12-14-31(18-23(21)15-20)13-11-19-6-9-24(10-7-19)29-27(32)26-16-22-3-1-2-4-25(22)30-26/h1-5,8,15-16,19,24,30H,6-7,9-14,18H2,(H,29,32)/t19-,24-

InChI key

JGLGOAQPUQITLD-OGAOHHHESA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Allosteric modulator of D2 dopamine receptors
SB269652 is an allosteric modulator of D2 dopamine receptors. SB269652 binds to an allosteric site that is distinct from the orthosteric bound by typical D2 antagonists and is only revealed in D2 receptor dimers. SB269652 is bitopic, binding to an orthosteric site one one partner in the dimer and the allosteric site in the other. Engagement of this secondary pocket at the extracellular end of TM2 and TM7 is a new mechanism of modulating binding of a ligand to the orthosteric site of a second protomer by a G-protein coupled receptor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000433546
0000433546
0000065860
055M4601V

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