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SML1302

Nap-FF

≥98% (HPLC)

Synonym(s):

(S)-2-[(S)-2-[2-(Naphthalen-6-yl)acetamido]-3-phenylpropanamido]-3-phenylpropanoic acid, 2-Naa-FF, N-[2-(2-Naphthalenyl)acetyl]-L-phenylalanyl-L-phenylalanine

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About This Item

Empirical Formula (Hill Notation):
C30H28N2O4
CAS Number:
946568-62-3
Molecular Weight:
480.55
NACRES:
NA.77
PubChem Substance ID:
329825771
UNSPSC Code:
12352200
MDL number:
MFCD28987468
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(O)=O)=O)CC3=CC4=CC=CC=C4C=C3

InChI

1S/C30H28N2O4/c33-28(20-23-15-16-24-13-7-8-14-25(24)17-23)31-26(18-21-9-3-1-4-10-21)29(34)32-27(30(35)36)19-22-11-5-2-6-12-22/h1-17,26-27H,18-20H2,(H,31,33)(H,32,34)(H,35,36)/t26-,27-/m0/s1

InChI key

IYVWBKAVHZILOI-SVBPBHIXSA-N

Biochem/physiol Actions

Nap-FF (2-Naa-FF) is a cell penetrant dipeptide that self-assembly and adopt the β-sheet structures to form prion-like nanofibrils of small molecules (PriSM). PriSM of Nap-FF are selectively cytotoxic to gliomas cancer cells in a presence of stromal cells. PriSM of Nap-FF selectively accumulate in cancer cells, impedes the dynamics of cytoskeletal filaments, and induces apoptosis.
Nap-FF is a cell penetrant dipeptide.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

hcodes

H301,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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