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SML1315

Ranirestat

≥97% (HPLC)

Synonym(s):

(3R)-2′-[(4-Bromo-2-fluorophenyl)methyl]-spiro[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-a]pyrazine]-1′,2,3′,5(2′H)-tetrone., AS-3201

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About This Item

Empirical Formula (Hill Notation):
C17H11BrFN3O4
CAS Number:
147254-64-6
Molecular Weight:
420.19
NACRES:
NA.77
PubChem Substance ID:
329825780
UNSPSC Code:
12352200
MDL number:
MFCD00920915
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥97% (HPLC)

form

powder

optical activity

[α]/D -5 to -10°, c = 1.0 in methanol

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

O=C(N1CC2=C(F)C=C(Br)C=C2)C3=CC=CN3[C@@]4(CC(NC4=O)=O)C1=O

InChI

1S/C17H11BrFN3O4/c18-10-4-3-9(11(19)6-10)8-21-14(24)12-2-1-5-22(12)17(16(21)26)7-13(23)20-15(17)25/h1-6H,7-8H2,(H,20,23,25)/t17-/m1/s1

InChI key

QCVNMNYRNIMDKV-QGZVFWFLSA-N

Related Categories

Biochem/physiol Actions

Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor.
Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor. Aldose reductase is a rate-limiting enzyme in the conversion of D-glucose to fructose via D-sorbitol. Ranirestat has been implicated in diabetic complications (cataract formation, retinopathy, neuropathy, nephropathy). Ranirestat prevents sorbitol accumulation and is thus hoped to be effective in the remedy of diabetic neuropathy.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000199791
0000199791
0000131410
0000058920
0000013981

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Global Trade Item Number

SKUGTIN
SML1315-5MG04061832724782
SML1315-25MG04061832724775

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