SML1317
XAP044
≥98% (HPLC)
Synonym(s):
7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one, XAP 044
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About This Item
Empirical Formula (Hill Notation):
C15H9IO4
CAS Number:
Molecular Weight:
380.13
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
protect from light
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C1C(OC2=CC=C(I)C=C2)=COC3=C1C=CC(O)=C3
InChI
1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
InChI key
XXZKJJYWINSUMJ-UHFFFAOYSA-N
Biochem/physiol Actions
XAP044 is a brain penetrant, potent and selective mGlu7 (metabotropic glutamate receptor subtype 7) antagonist that inhibits lateral amygdala long-term potentiation (LTP) in brain slices from wild type mice. XAP044 binds to a pocket localized in mGlu7′s extracellular Venus flytrap domain (VFTD) close to the binding site of the orthosteric agonist L-glutamate. XAP044 exhibits a wide-spectrum anti-stress, antidepressant- and anxiolytic-like efficacy in rodent behavioral model.
XAP044 is a brain penetrant, potent and selective mGlu7 antagonist.
Other Notes
Light sensitive. This compound has Iodine and should be kept in the dark.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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