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SML1332

NG25 trihydrochloride

≥98% (HPLC)

Synonym(s):

N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzamide trihydrochloride, NG 25 trihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C29H30F3N5O2 · 3HCl
CAS Number:
1315355-93-1
Molecular Weight:
646.96
NACRES:
NA.77
PubChem Substance ID:
329825790
UNSPSC Code:
12352200
MDL number:
MFCD19443255
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
protect from light
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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

H2O: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=CC=C(C(NC2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1OC4=C(C=CN5)C5=NC=C4

InChI

1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38)

InChI key

SMPGEBOIKULBCT-UHFFFAOYSA-N

Related Categories

Application

NG25 trihydrochloride has been used as a transforming growth factor β (TGFβ)-activated kinase 1 inhibitor (TAK1) in human umbilical vein endothelial cells (HUVECs) and pulmonary artery smooth muscle cells.

Biochem/physiol Actions

NG25 is multiple kinase inhibitor; potent dia; omjobotpr pf TAK1 and MAP4K2 kinases.
NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.

Other Notes

Light sensitive

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H413

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000203456
0000203457
0000203457
0000203456
0000131925

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Yaron Shav-Tal et al.
FEBS letters, 531(2), 109-114 (2002-11-06)
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Cell chemical biology, 24(8), 1029-1039 (2017-08-19)
Tumor necrosis factor alpha (TNF-α) has both positive and negative roles in human disease. In certain cancers, TNF-α is infused locally to promote tumor regression, but dose-limiting inflammatory effects limit broader utility. In autoimmune disease, anti-TNF-α antibodies control inflammation in
Lili Du et al.
American journal of physiology. Lung cellular and molecular physiology, 316(1), L20-L34 (2018-09-28)
TGFβ activation during newborn lung injury decreases the expression of pulmonary artery smooth muscle cell (PASMC)-soluble guanylate cyclase (sGC), a critical mediator of nitric oxide signaling. Using a rat PASMC line (CS54 cells), we determined how TGFβ downregulates sGC expression.
Ling-Yun Chu et al.
Scientific reports, 7(1), 12472-12472 (2017-10-01)
Pro-inflammatory cytokines are known to induce endothelial cell autophagy, but the role of autophagy in regulating the expression of pro-inflammatory molecules has not been characterized. We hypothesized that autophagy facilitates expression of endothelial adhesion molecules. TNFα and IL-1β induced autophagy
Noam Fallik et al.
Oncotarget, 8(65), 109575-109586 (2018-01-10)
Hematopoietic Stem Cells (HSCs) generate blood and immune cells through a hierarchical process of differentiation. Genes that regulate this process are of great interest for understanding normal and also malignant hematopoiesis. Surprisingly, however, very little is known about long-non-coding RNAs
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Global Trade Item Number

SKUGTIN
SML1332-5MG04061832451602
SML1332-25MG04061832451596

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