SML1344
AK-1
≥98% (HPLC)
Synonym(s):
3-[(Hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-benzamide
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About This Item
Empirical Formula (Hill Notation):
C19H21N3O5S
CAS Number:
Molecular Weight:
403.45
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C19H21N3O5S/c23-19(20-16-8-6-9-17(14-16)22(24)25)15-7-5-10-18(13-15)28(26,27)21-11-3-1-2-4-12-21/h5-10,13-14H,1-4,11-12H2,(H,20,23)
SMILES string
O=S(N1CCCCCC1)(C2=CC(C(NC3=CC=CC([N+]([O-])=O)=C3)=O)=CC=C2)=O
InChI key
HAYBKCHPEBZNGW-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Quality Level
Related Categories
Biochem/physiol Actions
AK-1 is a benzylsulfonamide. It acts as avia inhibiting of the nuclear factor-KB (NF-KB) /CSN2 (casein β) pathway.
AK-1 is a cell permeable, potent and specific SIRT2 inhibitor that induced proteasomal degradation of the Snail transcription factor.
AK-1 is a cell permeable, potent and specific SIRT2 inhibitor.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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AK-1, a specific SIRT2 inhibitor, induces cell cycle arrest by downregulating Snail in HCT116 human colon carcinoma cells.
Cheon M G, et al.
Cancer Letters, 356(2), 637-645 (2015)
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