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SML1344

AK-1

≥98% (HPLC)

Synonym(s):

3-[(Hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-benzamide

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About This Item

Empirical Formula (Hill Notation):
C19H21N3O5S
CAS Number:
330461-64-8
Molecular Weight:
403.45
NACRES:
NA.77
PubChem Substance ID:
329825801
UNSPSC Code:
12352200
MDL number:
MFCD01122550
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

O=S(N1CCCCCC1)(C2=CC(C(NC3=CC=CC([N+]([O-])=O)=C3)=O)=CC=C2)=O

InChI

1S/C19H21N3O5S/c23-19(20-16-8-6-9-17(14-16)22(24)25)15-7-5-10-18(13-15)28(26,27)21-11-3-1-2-4-12-21/h5-10,13-14H,1-4,11-12H2,(H,20,23)

InChI key

HAYBKCHPEBZNGW-UHFFFAOYSA-N

Biochem/physiol Actions

AK-1 is a benzylsulfonamide. It acts as avia inhibiting of the nuclear factor-KB (NF-KB) /CSN2 (casein β) pathway.
AK-1 is a cell permeable, potent and specific SIRT2 inhibitor that induced proteasomal degradation of the Snail transcription factor.
AK-1 is a cell permeable, potent and specific SIRT2 inhibitor.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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