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Merck
CN

SML1352

Sigma-Aldrich

CINK4

≥95% (HPLC)

Synonym(s):

trans-4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-cyclohexanol

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About This Item

Empirical Formula (Hill Notation):
C27H32N6O
CAS Number:
359886-84-3
Molecular Weight:
456.58
UNSPSC Code:
12352200
PubChem Substance ID:
329825807
NACRES:
NA.77

Key Documents

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Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 25 mg/mL, clear

storage temp.

2-8°C

SMILES string

O[C@@H]1CC[C@@H](NC2=CC(NCC)=NC(NC3=CC=C(N(CC4=CC=CC=C4)C=C5)C5=C3)=N2)CC1

InChI

1S/C27H32N6O/c1-2-28-25-17-26(29-21-8-11-23(34)12-9-21)32-27(31-25)30-22-10-13-24-20(16-22)14-15-33(24)18-19-6-4-3-5-7-19/h3-7,10,13-17,21,23,34H,2,8-9,11-12,18H2,1H3,(H3,28,29,30,31,32)/t21-,23-

InChI key

YVXCDLCJCIDFHE-AFARHQOCSA-N

Related Categories

Biochem/physiol Actions

CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes (IC50 = 1.5 mM). CINK4 has greater than 50 fold selectivity over CDK1 or CDK2. CINK4 dose-dependently inhibits phosphorylation of retinoblastoma (Rb) and induces G0-G1 cell cycle arrest and apoptosis in cancer cell lines.
CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
125M4747V

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