SML1352
CINK4
≥95% (HPLC)
Synonym(s):
trans-4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-cyclohexanol
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About This Item
Empirical Formula (Hill Notation):
C27H32N6O
CAS Number:
Molecular Weight:
456.58
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 25 mg/mL, clear
storage temp.
2-8°C
SMILES string
O[C@@H]1CC[C@@H](NC2=CC(NCC)=NC(NC3=CC=C(N(CC4=CC=CC=C4)C=C5)C5=C3)=N2)CC1
InChI
1S/C27H32N6O/c1-2-28-25-17-26(29-21-8-11-23(34)12-9-21)32-27(31-25)30-22-10-13-24-20(16-22)14-15-33(24)18-19-6-4-3-5-7-19/h3-7,10,13-17,21,23,34H,2,8-9,11-12,18H2,1H3,(H3,28,29,30,31,32)/t21-,23-
InChI key
YVXCDLCJCIDFHE-AFARHQOCSA-N
Biochem/physiol Actions
CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes (IC50 = 1.5 mM). CINK4 has greater than 50 fold selectivity over CDK1 or CDK2. CINK4 dose-dependently inhibits phosphorylation of retinoblastoma (Rb) and induces G0-G1 cell cycle arrest and apoptosis in cancer cell lines.
CINK4 is a specific inhbitor of CDK4/cyclin D1 complexes.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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