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Merck
CN

SML1353

ML351

≥98% (HPLC)

Synonym(s):

5-(Methylamino)-2-(1-naphthalenyl)-4-oxazolecarbonitrile, CID 664510, ML 351, SID 104223766

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About This Item

Empirical Formula (Hill Notation):
C15H11N3O
CAS Number:
Molecular Weight:
249.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CNC1=C(C#N)N=C(O1)C2=C3C(C=CC=C3)=CC=C2

InChI

1S/C15H11N3O/c1-17-15-13(9-16)18-14(19-15)12-8-4-6-10-5-2-3-7-11(10)12/h2-8,17H,1H3

InChI key

DYXYXTDIFMDJIR-UHFFFAOYSA-N

Biochem/physiol Actions

ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor that exhibits protective effects against oxidative glutamate toxicity in mouse neuronal HT22 cells. ML351 reduces infarct size in a mouse model of ischemic stroke.
ML351 is a cell penetrant, selective and highly potent human lipoxygenase-12/15 (15-Lipoxygenase-1, 12/15-LOX) inhibitor.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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