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SML1385

Lomitapide

Name: Lomitapide
Brand: SIGMA

≥98% (HPLC), microsomal triglyceride transfer protein (MTP) inhibitor, powder

Synonym(s):

AEGR-733, BMS-201038, N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]2-yl]carbonyl]amino]-1-piperidinyl]butyl]9H-fluoren-9-carboxamde

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About This Item

Empirical Formula (Hill Notation):

C₃₉H₃₇F₆N₃O₂

CAS Number:

182431-12-5

Molecular Weight:

693.72

UNSPSC Code:

51111800

PubChem Substance ID:

329825833

NACRES:

NA.77

MDL number:

MFCD16620494

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

Lomitapide, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NCC(F)(F)F)C1(C(C=CC=C2)=C2C3=C1C=CC=C3)CCCCN(CC4)CCC4NC(C5=C(C6=CC=C(C(F)(F)F)C=C6)C=CC=C5)=O

InChI

1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)

InChI key

MBBCVAKAJPKAKM-UHFFFAOYSA-N

Gene Information

human ... MTTP(4547), P4HB(5034)

Related Categories

Bioactive Small Molecules

Application

Lomitapide has been used as a microsomal triglyceride transfer protein (MTP) inhibitor to study its effects on very-low-density lipoproteins (VLDL) export in mouse hepatocytes.

Biochem/physiol Actions

Lomitapide can lower the secretion of very-low-density lipoproteins (VLDL) and chylomicrons.

Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).

Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP). Lomitapide has been shown to be highly effective in reducing LDL-cholesterol and triglycerides, and has been aproved for treatment of homozygous familial hypercholesterolemia.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

Simon J, et al.

Cell Metabolism, 31(3), 605-622 (2020)

Severe hypertriglyceridemia with pancreatitis: thirteen years? treatment with lomitapide

Sacks F M, et al.

JAMA Internal Medicine, 174(3), 443-447 (2014)

Severe hypertriglyceridemia with pancreatitis: thirteen years' treatment with lomitapide.

Frank M Sacks et al.

JAMA internal medicine, 174(3), 443-447 (2013-12-25)

Recurrent pancreatitis is a potentially fatal complication of severe hypertriglyceridemia. Genetic defects and lifestyle risk factors may render this condition unresponsive to current treatments. We report this first case of long-term management of intractable near-fatal recurrent pancreatitis secondary to severe

Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly.

Jorge Simon et al.

Cell metabolism, 31(3), 605-622 (2020-02-23)

Non-alcoholic steatohepatitis (NASH) is characterized by the accumulation of hepatic fat in an inflammatory/fibrotic background. Herein, we show that the hepatic high-activity glutaminase 1 isoform (GLS1) is overexpressed in NASH. Importantly, GLS1 inhibition reduces lipid content in choline and/or methionine

Global Trade Item Number

SKU	GTIN
SML1385-25MG	04061833058602
SML1385-5MG	04061833058619

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