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Merck
CN

SML1386

Calindol hydrochloride

≥98% (HPLC)

Synonym(s):

(R)-2-[[[1-(1-Naphthyl)ethyl]amino]methyl]-1H-indole hydrochloride, N-[(1R)-1-(1-naphthalenyl)ethyl]-1H-Indole-2-methanamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C21H20N2 · HCl
CAS Number:
729610-18-8
Molecular Weight:
336.86
NACRES:
NA.77
PubChem Substance ID:
329825834
UNSPSC Code:
12352200
MDL number:
MFCD18382212

Key Documents

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InChI

1S/C21H20N2.ClH/c1-15(19-11-6-9-16-7-2-4-10-20(16)19)22-14-18-13-17-8-3-5-12-21(17)23-18;/h2-13,15,22-23H,14H2,1H3;1H/t15-;/m1./s1

SMILES string

[H]Cl.C[C@@H](NCC1=CC2=C(N1)C=CC=C2)C3=CC=CC4=C3C=CC=C4

InChI key

KFILKQPBQZIRST-XFULWGLBSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Calcimimetic; Ca Sensing Receptor (CaSR) Agonist
Calindol is a calcimimetic Ca Sensing Receptor (CaSR) agonist. It is a positive allosteric modulator (PAM) with an EC50 value of 1 μM and a maximum stimulation of 130% of the 10mM Ca2+ activation in triggering PI hydrolysis.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000140845
0000054317
075M4768V

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