SML1392
FDI-6
≥98% (HPLC)
Synonym(s):
3-Amino-N-(4-fluorophenyl)-6-(2-thienyl)-4-(trifluoromethyl)-thieno[2,3-b]pyridine-2-carboxamide, 3-Amino-N-(4-fluorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide, NCGC00099374
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About This Item
Empirical Formula (Hill Notation):
C19H11F4N3OS2
CAS Number:
Molecular Weight:
437.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder (flocculent)
Quality Segment
assay
≥98% (HPLC)
form
powder (flocculent)
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
NC1=C(C(NC2=CC=C(F)C=C2)=O)SC3=C1C(C(F)(F)F)=CC(C4=CC=CS4)=N3
InChI
1S/C19H11F4N3OS2/c20-9-3-5-10(6-4-9)25-17(27)16-15(24)14-11(19(21,22)23)8-12(26-18(14)29-16)13-2-1-7-28-13/h1-8H,24H2,(H,25,27)
InChI key
ZATJMMZPGVDUOM-UHFFFAOYSA-N
Biochem/physiol Actions
Forkhead domain inhibitor-6 (FDI-6) is used to treat anaemia patients because of diminished red blood production. In Hep-2 cells, FDI-6 can stimulate cell death and also helps to prevent cell proliferation, invasion and migration.
FDI-6 is a potent and specific inhibitor of FOXM1 that blocks DNA binding. FDI-6 binds to FOXM1 protein and specifically downregulates FOXM1-activated genes.
FDI-6 is a potent and specific inhibitor of FOXM1.
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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