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SML1396

Heclin

≥98% (HPLC)

Synonym(s):

N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

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About This Item

Empirical Formula (Hill Notation):
C17H17NO3
CAS Number:
890605-54-6
Molecular Weight:
283.32
UNSPSC Code:
12352200
PubChem Substance ID:
329825844
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O

InChI

1S/C17H17NO3/c1-3-15-8-9-16(21-15)10-11-17(20)18-14-6-4-13(5-7-14)12(2)19/h4-11H,3H2,1-2H3,(H,18,20)/b11-10+

InChI key

SPTWXRJNCFIDRQ-ZHACJKMWSA-N

Application

Heclin has been used as a HECT-type ubiquitin E3 ligase inhibitor in human embryonic kidney (HEK293) cells. It has also been used to test its effect on dandelion-induced chloride channel protein (ClC-Ka) inhibition in HEK293 cells and fibroblast-like COS-7 cell line.

Biochem/physiol Actions

Heclin is not effective in inhibiting E1 or E2 proteins.
HECT E3 ubiquitin ligase inhibitor
Heclin is a selective reversible inihbitor of HECT E3 ubiquitin ligases. Heclin inhibited Nedd4, Smurf2 and WWP1 with IC50 values of 6.3 μM, 6.8 μM and 6.9 μM, respectively, and inhibited autoubiquitination of the Smurf2 HECT domain in vivo with an IC50 value of 9 μM. Heclin had no effect on the auto-ubiquitination of the RING domain ligase Mdm2.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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