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SML1401

XL413 hydrochloride

Name: XL413 hydrochloride
Brand: SIGMA

≥98% (HPLC), serine-threonine kinase CDC7 inhibitor, powder

Synonym(s):

(S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride, BMS-863233, XL-413

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₂ClN₃O₂ · xHCl

CAS Number:

1169562-71-3

Molecular Weight:

289.72 (free base basis)

UNSPSC Code:

12352200

PubChem Substance ID:

329825849

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Product Name

XL413 hydrochloride, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H₂O: 5 mg/mL, clear

storage temp.

−20°C

SMILES string

ClC1=CC2=C(C=C1)OC3=C2N=C([C@H]4NCCC4)NC3=O.C

InChI

1S/C14H12ClN3O2.CH4/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9;/h3-4,6,9,16H,1-2,5H2,(H,17,18,19);1H4/t9-;/m0./s1

InChI key

UYBMDYGAVMHMGF-FVGYRXGTSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Biochem/physiol Actions

XL413 is a selective inhibitor of the serine-threonine kinase CDC7 (cell division cycle 7 homolog), a regulator of cell cycle checkpoint control that has been implicated in protecting tumor cells from apoptotic cell death during replication stress. XL413 has an IC₅₀ of 3.4 nM for CDC7, compared to 215 nM, 42 nM and 18 nM for CK2, PIM1 and pMCM2, respectively. XL413 caused significant tumor growth regression in rodent models, causing cell cycle arrest in the late S to G2 phase.

XL413 is a selective inhibitor of the serine-threonine kinase CDC7.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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RIF1 controls replication initiation and homologous recombination repair in a radiation dose-dependent manner.

Yuichiro Saito et al.

Journal of cell science, 133(12) (2020-05-22)

RIF1 controls both DNA replication timing and the DNA double-strand break (DSB) repair pathway to maintain genome integrity. However, it remains unclear how RIF1 links these two processes following exposure to ionizing radiation (IR). Here, we show that inhibition of

The Global Phosphorylation Landscape of SARS-CoV-2 Infection.

Mehdi Bouhaddou et al.

Cell, 182(3), 685-712 (2020-07-10)

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. Here we present a

Global Trade Item Number

SKU	GTIN
SML1401-5MG	04061832451817
SML1401-25MG	04061832451800

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