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SML1404

A01 (Smurf1 inhibitor)

≥98% (HPLC)

Synonym(s):

[4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone

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About This Item

Empirical Formula (Hill Notation):
C22H20ClF3N4O3S
CAS Number:
1007647-73-5
Molecular Weight:
512.93
NACRES:
NA.77
PubChem Substance ID:
329825851
UNSPSC Code:
12352200
MDL number:
MFCD09320899
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=S(C1=CC=C(Cl)C(C(F)(F)F)=C1)(N2CCN(C(C3=CC=C(N4N=CC=C4C)C=C3)=O)CC2)=O

InChI

1S/C22H20ClF3N4O3S/c1-15-8-9-27-30(15)17-4-2-16(3-5-17)21(31)28-10-12-29(13-11-28)34(32,33)18-6-7-20(23)19(14-18)22(24,25)26/h2-9,14H,10-13H2,1H3

InChI key

QFYLTUDRXBNZFQ-UHFFFAOYSA-N

Biochem/physiol Actions

A01 is a high affinity selective inhibitor of E3 ubiquitin-protein ligase Smurf1 (Smad ubiquitination regulatory factor-1) that disturbs Smurf1-Smad1/5 interaction and blocks Smurf1 mediated Smad1/5 ubiquitination. A01 increases responsiveness to BMP-2 in myoblasts and osteoblasts.
A01 is a high affinity selective inhibitor of E3 ubiquitin-protein ligase Smurf1.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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