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SML1409

Madrasin

≥98% (HPLC)

Synonym(s):

2-(7-Methoxy-4-methyl-quinazolin-2-ylamino)-5,6-dimethyl-3H-pyrimidin-4-one, 2-[(7-Methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone (9CI), 4(1H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-(9CI), 4(3H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-, DDD00107587, RNAsplicing inhibitor

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About This Item

Empirical Formula (Hill Notation):
C16H17N5O2
CAS Number:
374913-63-0
Molecular Weight:
311.34
NACRES:
NA.77
PubChem Substance ID:
329825856
UNSPSC Code:
12352200
MDL number:
MFCD02233199
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

, white to dark brown

solubility

DMSO: 0.5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CC1=NC(NC(NC(C)=C2C)=NC2=O)=NC3=CC(OC)=CC=C31

InChI

1S/C16H17N5O2/c1-8-9(2)17-16(20-14(8)22)21-15-18-10(3)12-6-5-11(23-4)7-13(12)19-15/h5-7H,1-4H3,(H2,17,18,19,20,21,22)

InChI key

QQJIYKXTEMDJFM-UHFFFAOYSA-N

Application

Madrasin has been used as a spliceosome inhibitor to inhibit pre-mRNA processing in 3T3-L1 cells.

Biochem/physiol Actions

Madrasin is considered toxic to the cell at a higher concentration. At its minimal concentration, madrasin is known to induce subnuclear protein localization and cause cell cycle arrest.
Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin stalls spliceosome assembly at the A complex.
Madrasin is a potent and cell penetrant splicing inhibitor.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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