SML1420
FSL-1
≥80% (HPLC), Toll-like Receptor 2/6 agonist, powder
Synonym(s):
(R,S)-Pam2Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-OH, Fibroblast-stimulating Lipopeptide, Pam2CGDPKHPKSF, S-[2,3-Bis[(1-Oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-a-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine
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About This Item
Empirical Formula (Hill Notation):
C84H140N14O18S
CAS Number:
Molecular Weight:
1666.16
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥80% (HPLC)
Form:
powder
Product Name
FSL-1, ≥80% (HPLC)
Quality Segment
assay
≥80% (HPLC)
form
powder
color
white to off-white
solubility
H2O: soluble
storage temp.
−20°C
Biochem/physiol Actions
FSL-1 is a bacterial-derived toll-like receptor 2/6 agonist. It is capable of increasing resistance to herpes simplex virus type 2 (HSV-2) infection.
FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein that acts as a Toll-like Receptor 2/6 (TLR2/6) agonist and activator of nuclear transcription factor NF-K B.
FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein that acts as a Toll-like Receptor 2/6 (TLR2/6) agonist and activator of nuclear transcription factor NF-K B. FSL-1 is based on the N-terminal part of the 44-kDa lipoprotein LP44 of Mycoplasma salivarium. FSL-1 showed higher stimulatory activity than MALP-2 in its ability to induce TNF-α production in macrophages and NF-κ B in TLR2/TLR6 transfected HEK293 cells.
Preparation Note
Reconstitute in endotoxin-free water.
Other Notes
Air sensitive
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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