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Merck
CN

SML1424

Ac-YVAD-pNA

≥98% (HPLC)

Synonym(s):

Caspase-1 substrate (Chromogenic), N-α-acetyl-Tyr-Val-Ala-Asp-p-nitroanilide, N-acetyl-L-tyrosyl-L-valyl-L-alanyl-N-(4-nitrophenyl)-L-α-asparagine

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About This Item

Empirical Formula (Hill Notation):
C29H36N6O10
CAS Number:
149231-66-3
Molecular Weight:
628.63
NACRES:
NA.77
PubChem Substance ID:
329825867
UNSPSC Code:
12352200
MDL number:
MFCD00274387

Key Documents

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Product Name

Ac-YVAD-pNA, ≥98% (HPLC)

InChI

1S/C29H36N6O10/c1-15(2)25(34-28(42)22(31-17(4)36)13-18-5-11-21(37)12-6-18)29(43)30-16(3)26(40)33-23(14-24(38)39)27(41)32-19-7-9-20(10-8-19)35(44)45/h5-12,15-16,22-23,25,37H,13-14H2,1-4H3,(H,30,43)(H,31,36)(H,32,41)(H,33,40)(H,34,42)(H,38,39)/t16-,22-,23-,25-/m0/s1

SMILES string

O=C([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CC1=CC=C(O)C=C1)=O)=O)=O)NC2=CC=C([N+]([O-])=O)C=C2

InChI key

YDPNOCSPPGFBPX-XNHCRPTKSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Ac-YVAD-pNA is a chromogenic selective caspase-1 substrate
Ac-YVAD-pNA is a very selective chromogenic substrate for caspase-1, a key mediator of inflammatory processes formerly known as interleukin (IL)-1-converting enzyme. Ac-YVAD-pNA is used to determine caspase-1 activity. Cleavage of Ac-YVAD-pNA by caspase-1 releases pNA (p-nitroanilide), which can be quantified spectrophotometrically at 405 nm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000149066
0000153615
0000153615
0000149066
0000071350

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