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SML1450

Isobavachalcone

Name: Isobavachalcone
Brand: SIGMA

≥98% (HPCE), Akt inhibitor, powder

Synonym(s):

(2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one, 2′,4,4′-Trihydroxy-3′-(3-methyl-2-butenyl)-chalcone, Corylifolinin, Isobacachalcone

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₀O₄

CAS Number:

20784-50-3

Molecular Weight:

324.37

UNSPSC Code:

12352200

PubChem Substance ID:

329825889

NACRES:

NA.77

MDL number:

MFCD00902090

Assay:

≥98% (HPCE)

Form:

powder

Quality level:

100

Storage condition:

desiccated, protect from light

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Product Name

Isobavachalcone, ≥98% (HPCE)

Quality Level

100

assay

≥98% (HPCE)

form

powder

storage condition

desiccated, protect from light

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

OC1=C(CC=C(C)C)C(O)=C(C(/C=C/C2=CC=C(O)C=C2)=O)C=C1

InChI

1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+

InChI key

DUWPGRAKHMEPCM-IZZDOVSWSA-N

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Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

Isobavachalcone is a chalcone isolated from multipurpose medical plant Psoralea corylifolia that inhibits LPS-induced ICAM-1 expression and leukocyte adhesion to brain endothelial cells. It appears that isobavachalcone modulates both MyD88-dependent and TRIF-dependent signaling of toll-like receptor 4 (TLR4). Isobavachalcone significantly inhibits both oligomerization and fibrillization of Aβ42. Isobavachalcone exhibits a wide spectrum of biological activities including antioxidative, antiplatelet, antimicrobial, anti-inflammatory, antitumor, and neuroprotective.

Isobavachalcone is a chalcone isolated from multipurpose medical plant Psoralea corylifolia that inhibits LPS-induced ICAM-1 expression and leukocyte adhesion to brain endothelial cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Five Constituents in Psoralea corylifolia L. Attenuate Palmitic Acid-Induced Hepatocyte Injury via Inhibiting the Protein Kinase C-α/Nicotinamide-Adenine Dinucleotide Phosphate Oxidase Pathway.

Lishan Zhou et al.

Frontiers in pharmacology, 10, 1589-1589 (2020-03-03)

Psoralea corylifolia L. (PC) is a traditional Chinese herb used to treat yang deficiency of the spleen and kidney in pediatric disease. Our previous studies have found that PC can alleviate the liver oxidative stress of juvenile mice with nonalcoholic

Global Trade Item Number

SKU	GTIN
SML1450-25MG	04061832725079
SML1450-5MG	04061832725086

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