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Merck
CN

SML1462

Practolol

≥95% (HPLC)

Synonym(s):

(±)-Practolol, 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol, 4′-[2-Hydroxy-3-(isopropylamino)propoxy]acetanilidex, AY 21011, Dalzic, ICI 50172, N-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide

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About This Item

Empirical Formula (Hill Notation):
C14H22N2O3
CAS Number:
6673-35-4
Molecular Weight:
266.34
NACRES:
NA.77
PubChem Substance ID:
329825896
UNSPSC Code:
12352200
EC Number:
229-712-1
MDL number:
MFCD00864573

Key Documents

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InChI key

DURULFYMVIFBIR-UHFFFAOYSA-N

InChI

1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)

SMILES string

CC(NC1=CC=C(OCC(O)CNC(C)C)C=C1)=O

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Practolol is a potent and selective β-adrenoceptor antagonist.
Practolol is a potent and selective β-adrenoceptor antagonist. Practolol is a beta blocker that was discontinued to due to adverse reactions (keratoconjunctivitis sicca, conjunctival scarring, fibrosis, metaplasia, and shrinkage).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000199660
0000199660
0000145420
0000145421

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Jian-Qiao Cheng et al.
Molecules (Basel, Switzerland), 24(4) (2019-03-03)
This paper presents an application of high performance liquid chromatography coupled with quadrupole orbitrap high-resolution mass spectrometry (HPLC-Q-Orbitrap HRMS) for the analysis of 27 β-blockers and metabolites in milk powder. Homogenized milk power samples were extracted by acetonitrile and purified
Guohua Huang et al.
Combinatorial chemistry & high throughput screening, 19(2), 121-128 (2015-11-11)
It is crucial to identify the molecular targets of a compound during the course of the new drug discovery and drug development. Due to the complexity of biological systems, finding drug targets by biological experiments is very tedious and expensive.
Gerrit Müller et al.
Autophagy, 16(8), 1380-1395 (2019-11-02)
Oxidative stress and Th17 cytokines are important mediators of inflammation. Treatment with beta-adrenoceptor (ADRB) antagonists (beta-blockers) is associated with induction or aggravation of psoriasis-like skin inflammation, yet the underlying mechanisms are poorly understood. Herein, we identify lysosomotropic beta-blockers as critical

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