SML1462
Practolol
≥95% (HPLC)
别名:
(±)- 倍他洛尔, 1-(4-乙酰胺基苯氧基)-3-异丙基氨基-2-丙醇, 4′-[2-羟基-3-(异丙基氨基)丙氧基]乙酰苯胺, AY 21011, Dalzic, ICI 50172, N- [4- [2-羟基-3-[(1-甲基乙基)氨基]丙氧基]苯基]乙酰胺
质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 15 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CC(NC1=CC=C(OCC(O)CNC(C)C)C=C1)=O
InChI
1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)
InChI key
DURULFYMVIFBIR-UHFFFAOYSA-N
生化/生理作用
普拉洛尔是一种有效且选择性的β-肾上腺素受体拮抗剂。
普拉洛尔是一种有效且选择性的β-肾上腺素受体拮抗剂。 普拉洛尔是一种β受体阻滞剂,由于其不良反应(干燥性角膜结膜炎、结膜瘢痕、纤维化、化生和萎缩)而停止使用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jian-Qiao Cheng et al.
Molecules (Basel, Switzerland), 24(4) (2019-03-03)
This paper presents an application of high performance liquid chromatography coupled with quadrupole orbitrap high-resolution mass spectrometry (HPLC-Q-Orbitrap HRMS) for the analysis of 27 β-blockers and metabolites in milk powder. Homogenized milk power samples were extracted by acetonitrile and purified
Guohua Huang et al.
Combinatorial chemistry & high throughput screening, 19(2), 121-128 (2015-11-11)
It is crucial to identify the molecular targets of a compound during the course of the new drug discovery and drug development. Due to the complexity of biological systems, finding drug targets by biological experiments is very tedious and expensive.
Gerrit Müller et al.
Autophagy, 16(8), 1380-1395 (2019-11-02)
Oxidative stress and Th17 cytokines are important mediators of inflammation. Treatment with beta-adrenoceptor (ADRB) antagonists (beta-blockers) is associated with induction or aggravation of psoriasis-like skin inflammation, yet the underlying mechanisms are poorly understood. Herein, we identify lysosomotropic beta-blockers as critical
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