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Merck
CN

SML1467

ASP7663

≥98% (HPLC)

Synonym(s):

(2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid, (E)-[7-Fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]acetic acid

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About This Item

Empirical Formula (Hill Notation):
C14H14FNO3
CAS Number:
1190217-35-6
Molecular Weight:
263.26
UNSPSC Code:
12352200
PubChem Substance ID:
329825901
NACRES:
NA.77

Key Documents

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SMILES string

CC(C)CN(C1=C(F)C=CC=C1/C2=C\C(O)=O)C2=O

InChI

1S/C14H14FNO3/c1-8(2)7-16-13-9(4-3-5-11(13)15)10(14(16)19)6-12(17)18/h3-6,8H,7H2,1-2H3,(H,17,18)/b10-6+

InChI key

RCVZUIGCNAAMIC-UXBLZVDNSA-N

assay

≥98% (HPLC)

form

powder

color

light orange to dark orange

solubility

DMSO: 25 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

ASP7663 is a selective activator of transient receptor potential ankyrin 1 (TRPA1), known to play a role for chemical sensing in the pain pathway. ASP7663 activated human, rat, and mouse TRPA1 receptors with EC50 values of 510, 540, and 500 nM, respectively, and little or no affinity at more than 60 other related receptors, channels and enzymes. ASP7663 enhanced colonic motility and exerted analgesic effects against abdominal pain in mouse models.
ASP7663 is a selective activator of transient receptor potential ankyrin 1 (TRPA1).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000433538
0000433537
0000433537
0000433538
0000393084

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