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SML1469

Ulipristal acetate

≥98% (HPLC)

Synonym(s):

(11β)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione, CDB-2914

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About This Item

Empirical Formula (Hill Notation):
C30H37NO4
CAS Number:
126784-99-4
Molecular Weight:
475.62
NACRES:
NA.77
PubChem Substance ID:
329825903
UNSPSC Code:
51111800
MDL number:
MFCD00899035
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +165 to +185°, c = 1 in dichloromethane

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

O=C(C)[C@@]1(OC(C)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CCC4=C3[C@@H](C5=CC=C(N(C)C)C=C5)C[C@@]21C)=O

InChI

1S/C30H37NO4/c1-18(32)30(35-19(2)33)15-14-27-25-12-8-21-16-23(34)11-13-24(21)28(25)26(17-29(27,30)3)20-6-9-22(10-7-20)31(4)5/h6-7,9-10,16,25-27H,8,11-15,17H2,1-5H3/t25-,26+,27-,29-,30-/m0/s1

InChI key

OOLLAFOLCSJHRE-ZHAKMVSLSA-N

Gene Information

human ... PGR(5241)

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Biochem/physiol Actions

Ulipristal acetate is known to reduce uncontrolled bleeding due to post uterine fibroid surgery.
Ulipristal acetate is a selective progesterone receptor modulator (SPRM) with tissue-selective partial antagonist activity. It has clinical use both as an emergency contraceptive and as a treatment for uterine fibroids. Ulipristal acetate acts as a partial antagonist on the hypothalamic–pituitary–ovarian axis to inhibit or delay ovulation without affecting human embryo implantation. As a progesterone antagonist, Ulipristal acetate selectively suppresses neo-vascularization, cell proliferation, and survival in uterine fibroid cells, but not in normal myometrial cells.
Ulipristal acetate is a selective progesterone receptor modulator (SPRM); contraceptive and treatment for fibroid tumors.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361fd

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000518719
0000518719
0000407752
0000407756
0000407756

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Ulipristal acetate versus placebo for fibroid treatment before surgery.
Donnez J, et al.
The New England Journal of Medicine, 366(5), 409-420 (2012)

Global Trade Item Number

SKUGTIN
SML1469-50MG04061833034293
SML1469-10MG04061833034286

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