Skip to Content
Merck
CN

Key Documents

View All Documentation

SML1492

UMI-77

≥98% (HPLC)

Synonym(s):

2-[[4-[[(4-Bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C18H14BrNO5S2
CAS Number:
518303-20-3
Molecular Weight:
468.34
NACRES:
NA.77
PubChem Substance ID:
329825918
UNSPSC Code:
12352200
MDL number:
MFCD03471890
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

OC1=C(SCC(O)=O)C=C(NS(C2=CC=C(Br)C=C2)(=O)=O)C3=CC=CC=C31

InChI

1S/C18H14BrNO5S2/c19-11-5-7-12(8-6-11)27(24,25)20-15-9-16(26-10-17(21)22)18(23)14-4-2-1-3-13(14)15/h1-9,20,23H,10H2,(H,21,22)

InChI key

WUGANDSUVKXMEC-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

UMI-77 is an inhibitor of Induced myeloid leukemia cell differentiation protein Mcl-1, a member of the Bcl-2 family that inhibits apoptosis. UMI-77 acts by binding to the BH3-binding groove of Mcl-1, blocking the heterodimerization of Mcl-1/Bax and Mcl-1/Bak. UMI-77 is selective for Mcl-1 over other members of the antiapoptotic Bcl-2 family with a Ki of 490 nM. It inhibited cell growth and induced apoptosis in pancreatic cancer cells.
UMI-77 is an inhibitor of Induced myeloid leukemia cell differentiation protein Mcl-1.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000247291
0000247293
0000247293
0000247291
0000149653

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Global Trade Item Number

SKUGTIN
SML1492-25MG04061832926490
SML1492-5MG04061832926506

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service