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Merck
CN

SML1498

Cinepazide maleate

≥98% (HPLC)

Synonym(s):

(E)-1-[4-(2-Oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one maleate, 1-(Pyrrolidinyl-1-carbonyl)-methyl-4-(3,4,5-trimethoxycinnamoyl)-piperazine-maleate

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About This Item

Empirical Formula (Hill Notation):
C22H31N3O5 · C4H4O4
CAS Number:
26328-04-1
Molecular Weight:
533.57
NACRES:
NA.77
PubChem Substance ID:
329825922
UNSPSC Code:
12352125
MDL number:
MFCD01320526

Key Documents

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InChI key

XSTJTOKYCAJVMJ-GVTSEVKNSA-N

SMILES string

O=C(O)/C=C\C(O)=O.O=C(N1CCN(CC(N2CCCC2)=O)CC1)/C=C/C3=CC(OC)=C(OC)C(OC)=C3

InChI

1S/C22H31N3O5.C4H4O4/c1-28-18-14-17(15-19(29-2)22(18)30-3)6-7-20(26)25-12-10-23(11-13-25)16-21(27)24-8-4-5-9-24;5-3(6)1-2-4(7)8/h6-7,14-15H,4-5,8-13,16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b7-6+;2-1-

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

General description

Cinepazide maleate can be synthesized from ethyl chlorocarbonate activation and (E) 3,4,5-trimethoxycinnamylic acid.

Biochem/physiol Actions

Cinepazide maleate is a vasodilator used clinically in China used for the treatment of cardiovascular and cerebrovascular diseases, and peripheral vascular diseases.
Cinepazide maleate is a vasodilator used clinically in China used in China for the treatment of cardiovascular and cerebrovascular diseases, and peripheral vascular diseases. Cinepazide maleate is thought to act as a potentiator of adenosine A2 receptors and has also been characterized as a calcium channel blocker. It was withdrawn for agranulocytosis in several countries.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
016M4705V

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An Improved Synthesis of Cinepazide Maleate.
LIU, Hua-xiang, et al.
Fine Chemicals / ????, 10, 012-012 (2009)

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