SML1506
KY-05009
≥98% (HPLC)
Synonym(s):
5-(4-Methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide, 5-[(4-Methylbenzoyl)amino]-2-(phenylamino)-4-thiazolecarboxamide
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About This Item
Empirical Formula (Hill Notation):
C18H16N4O2S
CAS Number:
Molecular Weight:
352.41
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
light yellow to dark yellow
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
NC(C1=C(NC(C2=CC=C(C)C=C2)=O)SC(NC3=CC=CC=C3)=N1)=O
InChI
1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24)
InChI key
WCEDGRTWDSHZHF-UHFFFAOYSA-N
Biochem/physiol Actions
KY-05009 is also known as (5-(4-methylbenzamido)-2-(phenylamino) thiazole-4-carboxamide). It prevents the proliferation induced by interleukin-6 and promotes cell death by blocking Wnt signaling in multiple myeloma (MM) cells. KY-05009 is a novel aminothiazole, which possesses anti-cancer activity in human colorectal cancer cells. KY-05009 prevents migration and invasion stimulated by TGF-β1 (transforming growth factor beta 1).
KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells.
KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor.
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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