Skip to Content
Merck
CN

SML1508

C-DIM12

≥98% (HPLC)

Synonym(s):

3,3′-[(4-Chlorophenyl)methylene]bis-1H-indole, 4-Chlorophenyl-3,3′-diindolylmethane, 4-Chlorophenyldi-3-indolylmethane

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C23H17N2Cl
CAS Number:
178946-89-9
Molecular Weight:
356.85
UNSPSC Code:
12352200
PubChem Substance ID:
329825927
NACRES:
NA.77

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

C-DIM12, ≥98% (HPLC)

SMILES string

ClC(C=C1)=CC=C1C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5

InChI

1S/C23H17ClN2/c24-16-11-9-15(10-12-16)23(19-13-25-21-7-3-1-5-17(19)21)20-14-26-22-8-4-2-6-18(20)22/h1-14,23,25-26H

InChI key

LTLRXTDMXOFBDW-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

, light orange to dark red

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

C-DIM12 is a potent and selective nuclear receptor Nurr1 (NR4A2) activator that activates Nurr1 in urothelial carcinoma cells and in pancreatic cells. C-DIM12 suppresses inflammatory signaling in microglia.
C-DIM12 is a potent and selective nuclear receptor Nurr1 (NR4A2) activator.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000176745
0000143533
0000143533
0000143534

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Snehajyoti Chatterjee et al.
Neurobiology of aging, 85, 140-144 (2019-11-17)
Age-associated cognitive impairments affect an individual's quality of life and are a growing problem in society. Therefore, therapeutic strategies to treat age-related cognitive decline are needed to enhance the quality of life among the elderly. Activation of the Nr4a family
Qi-Wen Han et al.
Acta pharmacologica Sinica, 43(9), 2253-2266 (2022-02-09)
Neuroinflammation is closely related to the pathogenesis of neurodegenerative diseases. Activation of microglia, the resident immune cells in CNS, induces inflammatory responses, resulting in the release of neurotoxic molecules, which favors neuronal death and neurodegeneration. Nuclear receptor-related 1 (Nurr1) protein

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service