SML1509
MK6-83
≥98% (HPLC)
Synonym(s):
5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C16H20N2O2S2
CAS Number:
Molecular Weight:
336.47
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
[S](=O)(=O)(Nc2c(cccc2)N3CCCCC3)c1[s]c(cc1)C
InChI
1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3
InChI key
IRGYSXZCDAWOOC-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to brown
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel.
MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.
MK6-83 is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient?s Survival
Morelli MB, et al.
Cancers, 11(4), 525-525 (2019)
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