SML1513
SR1848
≥98% (HPLC)
Synonym(s):
6-[4-(3-Chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione, CDI 3238389, ML180
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About This Item
Empirical Formula (Hill Notation):
C20H25ClN4O2
CAS Number:
Molecular Weight:
388.89
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
O=C(N(C1CCCCC1)C(N2)=O)C=C2N3CCN(C4=CC(Cl)=CC=C4)CC3
InChI
1S/C20H25ClN4O2/c21-15-5-4-8-17(13-15)23-9-11-24(12-10-23)18-14-19(26)25(20(27)22-18)16-6-2-1-3-7-16/h4-5,8,13-14,16H,1-3,6-7,9-12H2,(H,22,27)
InChI key
CHMQQIFPOIZPIJ-UHFFFAOYSA-N
Application
SR1848 has been used as a liver receptor homolog 1 (LRH-1) inhibitor to study the role of LRH-1 in the regulation of lipopolysaccharide (LPS)-induced proinflammatory cytokines in mice macrophage. It has also been used as an LRH-1 inhibitor to study its effects on activation-induced Fas ligand (FasL) expression in the murine T-cell hybridoma cell line.
Biochem/physiol Actions
SR1848 is a cell penetrant and potent inhibitor of LRH-1.
SR1848 is a cell penetrant and potent inhibitor of orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) that reduces the expression of CyclinD1 and E1, which results in inhibition of cell proliferation. SR1848 induces rapid translocation of nuclear LRH-1 to the cytoplasm.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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