Skip to Content
Merck
CN

SML1530

SB-334867

≥98% (HPLC)

Synonym(s):

N-(2-Methyl-6-benzoxazolyl)-N′-1,5-naphthyridin-4-yl-urea, SB-334867, SB-334867A, SB334867

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C17H13N5O2
CAS Number:
792173-99-0
Molecular Weight:
319.32
NACRES:
NA.77
PubChem Substance ID:
329825947
UNSPSC Code:
51111800
MDL number:
MFCD06411602

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI

1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23)

SMILES string

O=C(NC1=CC=C(N=C(C)O2)C2=C1)NC3=CC=NC4=C3N=CC=C4

InChI key

AKMNUCBQGHFICM-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

Lateral hypothalamic orexin neuron activation leads to the development of morphine conditioned place preference, which is preferably blocked by SB-334867.
SB-334867 is a non-peptide selective antagonist of the orexin OX1 receptor.
SB-334867 is a non-peptide selective antagonist of the orexin OX1 receptor. SB-334867 blocks orexin-A induced calcium response with a pKb of 7.23. SB-334867 blocks increases in heart rate and body temperature induced by administratin of methamphetamine, and can inhibit the development of tolerance to the analgesic properties of morphine in rodent models. SB-334867 also shows anxiolytic and sedative effects.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315

Hazard Classifications

Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000053624
0000053625
0000053625
0000053624
0000160419

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high?fat food self?administration and reinstatement of food seeking in rats.
Nair S G, et al.
British Journal of Pharmacology, 154(2), 406-416 (2008)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service