SML1533
(±)-Marinopyrrole A
≥95% (HPLC)
Synonym(s):
(±)-Maritoclax, 1,1′-(4,4′,5,5′-Tetrachloro[1,3′-bi-1H-pyrrole]-2,2′-diyl)bis[1-(2-hydroxyphenyl)-methanone
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About This Item
Empirical Formula (Hill Notation):
C22H12Cl4N2O4
CAS Number:
Molecular Weight:
510.15
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
light yellow to dark yellow
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
SMILES string
Clc1[n](c(cc1Cl)C(=O)c4c(cccc4)O)c2c([nH]c(c2Cl)Cl)C(=O)c3c(cccc3)O
InChI
1S/C22H12Cl4N2O4/c23-12-9-13(19(31)10-5-1-3-7-14(10)29)28(22(12)26)18-16(24)21(25)27-17(18)20(32)11-6-2-4-8-15(11)30/h1-9,27,29-30H
InChI key
QYPJBTMRYKRTFG-UHFFFAOYSA-N
General description
Marinopyrrole A (Maritoclax) is a member of phenolic 1,3′-bipyrroles family targeting actin group.
Biochem/physiol Actions
Marinopyrrole A (Maritoclax) is a potent and selective inhibitor of Bcl-2 family member Mcl-1, originally isolated from marine streptomycetes for its antimicrobial activity against methicillin-resistant Staphylococcus aureus. Marinopyrrole A directly binds to Mcl-1 and targets it for proteasomal degradation. Marinopyrrole A induced apoptosis in Mcl-1-dependent cancer cells and sensitized cancer cells to ABT-737.
Marinopyrrole A (Maritoclax) is a potent and selective inhibitor of Bcl-2 family member Mcl-1; antibiotic.
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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