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SML1538

NMDI14

Name: NMDI14
Brand: SIGMA

≥97% (HPLC), nonsense-mediated RNA decay inhibitor, powder

Synonym(s):

4,5-Dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-3-thiophenecarboxylic acid ethyl ester, Ethyl 2-{[(6,7–dimethyl–3-oxo-1,2,3,4-tetrahydro-2-quinoxalinyl)acetyl]amino}-4,5-dimethyl-3-thiophenecarboxylate

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₅N₃O₄S

CAS Number:

307519-88-6

Molecular Weight:

415.51

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥97% (HPLC)

Form:

powder

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Properties

Product Name

NMDI14, ≥97% (HPLC)

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 0.2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[s]1c(c(c(c1C)C)C(=O)OCC)NC(=O)CC2Nc3c(cc(c(c3)C)C)NC2=O

InChI key

QRLPSNLBUMVXBL-UHFFFAOYSA-N

Description

Application

NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:

to study its effects on differentiating cardiomyocytes
to study its effects on zebrafish pdzk1 gene-knockout embryos
to analyze its effects on the apoptosis of colorectal cancer cells

Biochem/physiol Actions

NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.

Potent nonsense-mediated RNA decay (NMD) inhibitor

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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