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SML1556

AEM1

≥98% (HPLC)

Synonym(s):

ARE expression modulator 1, N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine

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About This Item

Empirical Formula (Hill Notation):
C20H14FN3O2S
CAS Number:
1030123-90-0
Molecular Weight:
379.41
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to light brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

Fc1ccc(cc1)c2c3c([s]c2)[nH]cn[c]3=NCc4cc5c(cc4)OCO5

InChI

1S/C20H14FN3O2S/c21-14-4-2-13(3-5-14)15-9-27-20-18(15)19(23-10-24-20)22-8-12-1-6-16-17(7-12)26-11-25-16/h1-7,9-10H,8,11H2,(H,22,23,24)

InChI key

QGYLTGSHWIGJJD-UHFFFAOYSA-N

Biochem/physiol Actions

AEM1 (ARE expression modulator 1) is also a selective inhibitor of sirtuin 2, which is a protein deacetylase mediated by NAD+. Sirtuin 2 supports tumor cell proliferation, thus its inhibition stimulates cell death in tumors.
AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity.
AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity. AEM1 broadly decreases the expression of NRF2 controlled genes and sensitizes A549 cells to various chemotherapeutic agents.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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