SML1558
Yoda1
≥98% (HPLC), powder, Piezo1 agonist
Synonym(s):
2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine
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About This Item
Empirical Formula (Hill Notation):
C13H8Cl2N4S2
CAS Number:
Molecular Weight:
355.27
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
Yoda1, ≥98% (HPLC)
SMILES string
[s]1c(nnc1c3nccnc3)SCc2c(cccc2Cl)Cl
InChI key
BQNXBSYSQXSXPT-UHFFFAOYSA-N
InChI
1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
Application
Yoda1 has been used to investigate its effect on heterotrimeric Piezo1 channels.
Biochem/physiol Actions
Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.
General description
Yoda1 is a novel synthetic small molecule developed to study the kinetics, regulation and function of the cation channel Piezo-type mechanosensitive ion channel component 1 (Piezo1).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Lei Liu et al.
Frontiers in pharmacology, 12, 606245-606245 (2021-04-13)
XueShuanTong (XST) comprising therapeutically active ginsenosides, a lyophilized extract of Panax notoginseng roots, is extensively used in traditional Chinese medicine to treat ischemic heart and cerebrovascular diseases. Our recent study shows that treatment with XST inhibits shear-induced thrombosis formation but
Chemical gating of the mechanosensitive Piezo1 channel by asymmetric binding of its agonist Yoda1.
Lacroix JJ, et al.
bioRxiv, 169516-169516 (2017)
Jerome J Lacroix et al.
Nature communications, 9(1), 2029-2029 (2018-05-26)
Piezo proteins are transmembrane ion channels which transduce many forms of mechanical stimuli into electrochemical signals. Their pore, formed by the assembly of three identical subunits, opens by an unknown mechanism. Here, to probe this mechanism, we investigate the interaction
Immacolata Andolfo et al.
American journal of hematology, 95(2), 188-197 (2019-11-19)
Dehydrated hereditary stomatocytosis (DHS), or xerocytosis, is an autosomal dominant hemolytic anemia. Most patients with DHS carry mutations in the PIEZO1 gene encoding a mechanosensitive cation channel. We here demonstrate that patients with DHS have low levels of hepcidin and
Erika Sugisawa et al.
Cell, 182(3), 609-624 (2020-07-09)
Gastrointestinal enterochromaffin cells regulate bone and gut homeostasis via serotonin (5-hydroxytryptamine [5-HT]) production. A recent report suggested that gut microbes regulate 5-HT levels; however, the precise underlying molecular mechanisms are unexplored. Here, we reveal that the cation channel Piezo1 in
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