SML1559
Furamidine dihydrochloride
≥98% (HPLC)
Synonym(s):
2,5-Bis(4-amidinophenyl)furan dihydrochloride, 4,4′-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride, DB 75, DB75, NSC 305831, WR199385
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About This Item
Empirical Formula (Hill Notation):
C18H16N4O · 2HCl
CAS Number:
Molecular Weight:
377.27
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 1 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
[Cl-].[Cl-].N[C+](N)c1ccc(cc1)c2[o]c(cc2)c3ccc(cc3)[C+](N)N
InChI
1S/C18H16N4O.2ClH/c19-17(20)13-5-1-11(2-6-13)15-9-10-16(23-15)12-3-7-14(8-4-12)18(21)22;;/h1-10H,(H3,19,20)(H3,21,22);2*1H
InChI key
VXNYQUQHOUERTR-UHFFFAOYSA-N
General description
Furamidine dihydrochloride is an analog of the aromatic drug pentamidine and a substrate of the organic cation transporter 1 (OCT1). A number of prodrugs of furamidine dihydrochloride are being synthesised and are in clinical trial stages.
Biochem/physiol Actions
Furamidine (DB75) binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine was originally developed as an anti-parasitic compound for a variety of diseases including Chagas′ disease. Furamidine targets AT rich sequences in trypanosome kinetoplast minicircle DNA (kDNA), resulting in subsequent destruction of the kinetoplast and cell death. Furamidine has also been found to inihbit tyrosyl-DNA phosphodiesterase (Tdp1) and act as a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4μM.
Storage Class
11 - Combustible Solids
wgk
WGK 3
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