SML1567
MCB-613
≥98% (HPLC)
Synonym(s):
4-Ethyl-2,6-bis(pyridin-3-ylmethylene)cyclohexanone
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About This Item
Empirical Formula (Hill Notation):
C20H20N2O
CAS Number:
Molecular Weight:
304.39
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
General description
Application
MCB-613 has been used to study the molecular mechanism of MCB-613-induced cell death.
Biochem/physiol Actions
MCB-613 is capable of inducing the transcriptional activity of steroid receptor coactivators (SRCs).
MCB-613 is a pan-Steroid Receptor Coactivator (SRC) stimulator. There are three steroid receptor coactivators (SRC) that interact with transcription factors and whose overexpression is assciated with a number of cancers, particularly breast cancer. MCB-613 overstimulates SRC activity in cancer cells resulting in excessive generation of reactive oxygen species (ROS), leading to cell stress and death by a process called paraptosis. MCB-613 is a cytotoxic molecule which can kill various human cancer cell lines, like HepG2 (liver), PC-3 (prostate) and MCF-7 (breast) cells.
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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